Fatzo Mouse 
Introduction
• The Fatzo mouse model mimics the characteristics of Metabolic Syndrome and polygenic obesity.
• Selective breeding has resulted in a strain that exhibits obesity, insulin resistance, and moderate hyperglycemia (300-350 mg/dl).
• Having a functional leptin receptor, this polygenic obesity model may be a better choice in many pk/pd studies of anti-obesity and anti-diabetic compounds due its characteristics that more closely mimic those of the human condition.
Characteristics
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Weight gain is rapid; comparable to db/db or ob/ob. (Fig. 1) (Fig. 2)
Males begin to express and maintain hyperglycemia at 14 weeks of age. (
Fig. 3) (
Fig. 5)
Insulin resistance develops at a rapid rate. (
Fig. 4)
(Fig. 6)
Leptin levels are maintained. (Fig.
6)
Benefits
More closely reflect human conditions.
Obese and hyperglycemic without defects in leptin or leptin receptor.
Has the characteristics of metabolic syndrome.
Can replace the DIO, db/db, or ob/ob mice.
Insulin resistant, hyperglycemic, and glucose intolerant.
Phenotype is expressed using a standard chow diet.
Availability
Fatzo is currently being production bred for commercialization.
Limited availability through 2007.
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