Zucker Diabetic Sprague Dawley (ZDSD)

Introduction

In response to the increasing need of a rodent model that is less monogenic in its mutation which causes diabetes and obesity, the team at PreClinOmics, Inc. has developed the ZDSD rat model.

The ZDSD is developed by crossing the Levin DIO (Diet-Induced Obesity) rat derived from the CRL CD (exhibiting insulin resistance and polygenic obesity) strain with a homozygous lean ZDF rat (expressing beta cell failure with the fa/fa genotype).

Selective breeding results in a strain that exhibits obesity and overt diabetes.

This polygenic obesity model may be better to use in many pk/pd studies of anti-obese and anti-diabetes compounds due its characteristics that more closely mimic those of human diabetes.

Characteristics

Download study data - [PDF, 7.5 MB]

Weight gain is rapid. (Fig. 1) (Fig. 2) (Fig. 3)
As diabetes develops, weight begins to decrease. (Fig. 1) (Fig. 2) (Fig. 3)
Hyperglycemia develops 13-25 weeks of age. (Fig. 3) (Fig. 4)
As hyperglycemia develops, insulin levels rise, then decline. (Fig. 5) (Fig. 6) (Fig. 8)
Cholesterol and triglycerides tend to be elevated in diabetic males. (Fig. 7) (Fig. 16)

Benefits

Polygenic obesity can be modulated by diet.
Treatments help prevent the onset of diabetes.
No defects in leptin production/leptin receptors. (Fig. 8) (Fig. 15)
Slower onset of diabetes. (Fig. 1) (Fig. 3) (Fig. 4) (Fig. 6) (Fig. 12)
Insulin resistance develops as animals age and gain weight. (Fig. 5) (Fig. 3) (Fig. 6) (Fig. 8) (Fig. 14)
Pancreatic failure may go more slowly.

Uses

Obesity model (Fig. 1) (Fig. 2)
Diabetes model (natural/spontaneous & diet-induced/modulated)- (Fig. 1) (Fig. 3) (Fig. 4) (Fig. 5) (Fig. 6) (Fig. 12) (Fig. 14)