Resources
Publications:
Preclinical and Clinical Anti-obesity and Anti-diabetes Targets
Scientific Articles:
ZDF:
Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise.Kiraly MA, Bates HE, Yue JT, Goche-Montes D, Fediuc S, Park E, Matthews SG, Vranic M, Riddell MC. Metabolism. 2007 Jun;56(6):732-44.
Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: the role of hydronephrosis.Marsh SA, Powell PC, Agarwal A, Dell'italia LJ, Chatham JC. Am J Physiol Heart Circ Physiol. 2007 Mar 9; [Epub ahead of print].
Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: implications for obesity treatment. Park BH, Wang MY, Lee Y, Yu X, Ravazzola M, Orci L, Unger RH. J Biol Chem. 2006 Dec 29;281(52):40283-91. Epub 2006 Oct 12.
Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats. Fujimoto Y, Torres TP, Donahue EP, Shiota M. Diabetes. 2006 Sep;55(9):2479-90.
Ectopic expression of glucagon-like peptide 1 for gene therapy of type II diabetes. Parsons GB, Souza DW, Wu H, Yu D, Wadsworth SG, Gregory RJ, Armentano D. Gene Ther. 2007 Jan;14(1):38-48. Epub 2006 Aug 24.
Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions. Fyfe MC, White JR, Taylor A, Chatfield R, Wargent E, Printz RL, Sulpice T, McCormack JG, Procter MJ, Reynet C, Widdowson PS, Wong-Kai-In P. Diabetologia. 2007 Jun;50(6):1277-87. Epub 2007 Apr 6.
Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance.Zinker B, Mika A, Nguyen P, Wilcox D, Ohman L, von Geldern TW, Opgenorth T, Jacobson P. Metabolism. 2007 Mar;56(3):380-7
Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. Thyfault JP, Cree MG, Zheng D, Zwetsloot JJ, Tapscott EB, Koves TR, Ilkayeva O, Wolfe RR, Muoio DM, Dohm GL. 2007 Feb;292(2):C729-39. Epub 2006 Oct 18.
OBESITY:
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 11 May 2007: Vol. 316. no. 5826, pp. 889-894.
Variation in FTO contributes to childhood obesity and severe adult obesity. Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougneres P, Kovacs P, Marre M, Balkau B, Cauchi S, Chevre JC, Froguel P. Nat Genet. 2007 Jun;39(6):724-6. Epub 2007 May 13.
Low Carbohydrate, High Fat Diet Increases C-Reactive Protein during Weight Loss. Rankin JW, Turpyn AD. J Am Coll Nutr. 2007 Apr;26(2):163-9.
Obesity as a cardiovascular risk factor. Sowers JR. Am J Med. 2003 Dec 8;115 Suppl 8A:37S-41S.
Induction of cytochrome promotes liver injury in ob/ob mice. Dey A, Cederbaum AI. Hepatology. 2007 May 30;45(6):1355-1365 [Epub ahead of print]
The impact of obesity on prostate cancer. van Roermund JG, Witjes JA. World J Urol. 2007 May 30; [Epub ahead of print]
Massive weight loss decreases corticosteroid-binding globulin levels and increases free cortisol in healthy obese patients: an adaptive phenomenon? Manco M, Fernandez-Real JM, Valera-Mora ME, Dechaud H, Nanni G, Tondolo V, Calvani M, Castagneto M, Pugeat M, Mingrone G. Diabetes Care. 2007 Jun;30(6):1494-500.
DIABETES:
Early-phase insulin secretion is disturbed in obese subjects with glucose intolerance.Mizuno A, Arai H, Fukaya M, Sato M, Hisami YO, Takeda E, Doi T. Metabolism. 2007 Jun;56(6):856-62
Effect of pioglitazone therapy in lean type1 diabetes mellitus. Bhat R, Bhansali A, Bhadada S, Sialy R. Diabetes Res Clin Pract. 2007 May 30; [Epub ahead of print].
All beta Cells Contribute Equally to Islet Growth and Maintenance Brennand K, Huangfu D, Melton D. PLoS Biol. 2007 May 29;5(7):e163 [Epub ahead of print]
Combination of dipeptidylpeptidase IV inhibitor and low dose thiazolidinedione: Preclinical efficacy and safety in db/db mice. Roy S, Khanna V, Mittra S, Dhar A, Singh S, Mahajan DC, Priyadarsiny P, Davis JA, Sattigeri J, Saini KS, Bansal VS. Life Sci. 2007 May 1; [Epub ahead of print].
Angiotensin II and Endothelin-1 augment the vascular complications of diabetes via JAK2 activation. Banes-Berceli AK, Ketsawatsomkron P, Ogbi S, Patel B, Pollock DM, Marrero MB. Am J Physiol Heart Circ Physiol. 2007 May 25; [Epub ahead of print]
Altered activity of 11{beta} hydroxysteroid dehydrogenase type 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes.Jang C, Obeyesekere VR, Dilley RJ, Krozowski Z, Inder WJ, Alford FP. J Clin Endocrinol Metab. 2007 May 22; [Epub ahead of print].
Reduced Incretin Effect in Type 2 Diabetes - Cause or Consequence of the Diabetic State? Knop FK, Vilsboll T, Hojberg PV, Larsen S, Madsbad S, Volund A, Holst JJ, Krarup T. Diabetes. 2007 May 18; [Epub ahead of print].
METABOLIC SYNDROME:
Evidence for distinct effects of GH and IGF-I in the metabolic syndrome. Maison P, Balkau B, Souberbielle JC, Cunin P, Vol S, Macquin-Mavier I, Eschwege E; the D. E. S. I. R. Study Group. Diabet Med. 2007 May 29; [Epub ahead of print].
Association of Metabolic Syndrome with Microalbuminuria in Non-Hypertensive Type 2 Diabetic Patients.Lee JE, Huh W, Son HJ, Kim YG, Kim DJ, Lee MK, Oh HY. Nephron Clin Pract. 2007 May 22;106(3):c98-c103 [Epub ahead of print]
Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Mol Cell Biochem. 2007 May 15; [Epub ahead of print]
Metabolic syndrome increases the risk of ischemic stroke in women. Takahashi K, Bokura H, Kobayashi S, Iijima K, Nagai A, Yamaguchi S. Intern Med. 2007;46(10):643-8. Epub 2007 May 24.
Nuclear magnetic resonance-determined lipoprotein abnormalities in nonhuman primates with the metabolic syndrome and type 2 diabetes mellitus.Ding SY, Tigno XT, Hansen BC. Metabolism. 2007 Jun;56(6):838-46.
The evaluation of the role of beta-hydroxy fatty acids on chronic inflammation and insulin resistance.Soydan AS, Dokmetas HS, Cetin M, Koyuncu A, Kaptanoglu E, Elden H. Mediators Inflamm. 2006;2006(5):64980.