Fatzo Mouse
Introduction – The Fatzo mouse model mimics the characteristics of Metabolic Syndrome and polygenic obesity.
Selective breeding has resulted in a strain that exhibits obesity, insulin resistance, and moderate hyperglycemia (300-350 mg/dl).
Having a functional leptin receptor, this polygenic obesity model may be a better choice in many pk/pd studies of anti-obesity and anti-diabetic compounds due its characteristics that more closely mimic those of the human condition.
Health Reports
PreClinOmics Health Monitoring Program
Characteristics
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- Weight gain is rapid; comparable to db/db or ob/ob.
- Males begin to express and maintain hyperglycemia at 14 weeks of age.
- Insulin resistance develops at a rapid rate.
- Leptin levels are maintained.
Benefits
- More closely reflect human conditions.
- Obese and hyperglycemic without defects in leptin or leptin receptor.
- Has the characteristics of metabolic syndrome.
- Can replace the DIO, db/db, or ob/ob mice.
- Insulin resistant, hyperglycemic, and glucose intolerant.
- Phenotype is expressed using a standard chow diet.
Availability
- Fatzo is currently being production bred for commercialization. Contact us to discuss your needs.
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