The ZDSD Rat – A model of Metabolic Syndrome

 Characteristics

• Spontaneously exhibits obesity, hyperglycemia, insulin resistance and hyperlipidemia
• Phenotype can be modulated by diet
• Disease complications lead to Type II Diabetes
• No defects in Leptin or Leptin receptor

Health Reports

PreClinOmics Health Monitoring Program

ZDSD Health Report

• Onset of Diabetes
• Body Composition
• Insulin Sensitivity
• Reference Compound Efficacy
• Osteoperosis
• Serum Markers
  • Metabolic Syndrome
  • Renal Disease
  • Vascular Disease
  • Inflammation

Onset of Diabetes

 

Body Composition


 
Insulin Sensitivity





 
Reference Compound Efficacy









 
Bone






 
Serum Markers of Metabolic Disease






 
Serum Markers of Renal Disease







 
The ZDSD as a model for diabetic nephropathy

Serum Markers of Vascular Disease







 

Serum Markers of Inflammation